Cyclazocine

Cyclazocine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Identifiers
  • 3-(Cyclopropylmethyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
    or
    2-Cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.627 Edit this at Wikidata
Chemical and physical data
FormulaC18H25NO
Molar mass271.404 g·mol−1
3D model (JSmol)
  • Oc1ccc4c(c1)C2(C(C(N(CC2)CC3CC3)C4)C)C
  • InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3 checkY
  • Key:YQYVFVRQLZMJKJ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. This family of opioid drugs is called the benzomorphans or benzazocines.[1] It is a KOR agonist and MOR partial agonist, and also has high affinity for the DOR.[2]

  1. ^ Archer S, Glick SD, Bidlack JM (November 1996). "Cyclazocine revisited". Neurochemical Research. 21 (11): 1369–1373. doi:10.1007/BF02532378. PMID 8947927. S2CID 680860.
  2. ^ Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP (July 2002). "8-Carboxamidocyclazocine: a long-acting, novel benzomorphan". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 374–380. doi:10.1124/jpet.302.1.374. PMID 12065740. S2CID 15864569.