| 3',5'-cyclic nucleotide phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Phosphodiesterase 4D hexamer, Human | |||||||||
| Identifiers | |||||||||
| Symbol | PDEase_I | ||||||||
| Pfam | PF00233 | ||||||||
| InterPro | IPR002073 | ||||||||
| PROSITE | PDOC00116 | ||||||||
| SCOP2 | 1f0j / SCOPe / SUPFAM | ||||||||
| CDD | cd00077 | ||||||||
| |||||||||
| 3′,5′-cyclic-nucleotide phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.17 | ||||||||
| CAS no. | 9040-59-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate to a nucleoside 5′-phosphate:
- nucleoside 3′,5′-cyclic phosphate + H2O = nucleoside 5′-phosphate
They thus control the cellular levels of the cyclic second messengers and the rates of their degradation.[1] Some examples of nucleoside 3′,5′-cyclic phosphate include:
- 3′,5′-cyclic AMP
- 3′,5′-cyclic dAMP
- 3′,5′-cyclic IMP
- 3′,5′-cyclic GMP
- 3′,5′-cyclic CMP
There are 11 distinct phosphodiesterase families (PDE1–PDE11) with a variety in isoforms and splicing having unique three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities.[1]