Cyclin-dependent kinase 1

CDK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YC6, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cyclin dependent kinase 1
External IDs	OMIM: 116940; MGI: 88351; HomoloGene: 68203; GeneCards: CDK1; OMA:CDK1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.2 Start 60,778,331 bp[1] End 60,794,852 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B5.3|10 36.07 cM Start 69,170,976 bp[2] End 69,188,768 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence trabecular bone secondary oocyte gonad rectum bone marrow tibia appendix cartilage tissue Top expressed in maxillary prominence mandibular prominence morula morula ventricular zone fetal liver hematopoietic progenitor cell epiblast medial ganglionic eminence abdominal wall somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity histone kinase activity kinase activity Hsp70 protein binding protein binding RNA polymerase II CTD heptapeptide repeat kinase activity ATP binding protein serine/threonine kinase activity chromatin binding cyclin binding cyclin-dependent protein kinase activity cyclin-dependent protein serine/threonine kinase activity virus receptor activity Cellular component centrosome membrane spindle nucleoplasm microtubule organizing center midbody spindle microtubule mitochondrion mitotic spindle extracellular exosome cytoskeleton nucleus cyclin-dependent protein kinase holoenzyme complex cytoplasm cytosol mitochondrial matrix endoplasmic reticulum membrane cyclin B1-CDK1 complex Biological process positive regulation of protein localization to nucleus centrosome cycle regulation of embryonic development response to cadmium ion epithelial cell differentiation response to organic cyclic compound phosphorylation response to copper ion positive regulation of mitotic cell cycle negative regulation of apoptotic process pronuclear fusion response to activity regulation of Schwann cell differentiation cell division positive regulation of DNA replication DNA replication mitotic nuclear membrane disassembly positive regulation of gene expression positive regulation of cardiac muscle cell proliferation chromosome condensation G2/M transition of mitotic cell cycle response to axon injury peptidyl-serine phosphorylation animal organ regeneration response to organonitrogen compound response to amine DNA repair cell cycle anaphase-promoting complex-dependent catabolic process microtubule cytoskeleton organization response to ethanol mitotic G2 DNA damage checkpoint signaling Golgi disassembly peptidyl-threonine phosphorylation cell migration ventricular cardiac muscle cell development response to toxic substance response to hydrogen peroxide cellular response to hydrogen peroxide protein localization to kinetochore apoptotic process cell population proliferation proteasome-mediated ubiquitin-dependent protein catabolic process mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of gene expression regulation of meiotic cell cycle ciliary basal body-plasma membrane docking protein phosphorylation positive regulation of G2/M transition of mitotic cell cycle protein deubiquitination mitotic cell cycle phase transition positive regulation of mitochondrial ATP synthesis coupled electron transport viral entry into host cell regulation of G2/M transition of mitotic cell cycle transcription initiation from RNA polymerase II promoter protein-containing complex assembly regulation of mitotic cell cycle phase transition regulation of circadian rhythm Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 983 12534 Ensembl ENSG00000170312 ENSMUSG00000019942 UniProt P06493 P11440 RefSeq (mRNA) NM_001130829 NM_001170406 NM_001170407 NM_001786 NM_033379 NM_001320918 NM_007659 RefSeq (protein) NP_001163877 NP_001163878 NP_001307847 NP_001777 NP_203698 NP_031685 Location (UCSC) Chr 10: 60.78 – 60.79 Mb Chr 10: 69.17 – 69.19 Mb PubMed search [3] [4]
Wikidata
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Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation.^[5] It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively.^[6] With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.^[7]