Cyclin-dependent kinase 5

CDK5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDK5, Cdk5, AW048668, Crk6, LIS7, PSSALRE, cyclin-dependent kinase 5, cyclin dependent kinase 5
External IDsOMIM: 123831; MGI: 101765; HomoloGene: 3623; GeneCards: CDK5; OMA:CDK5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164410
NM_004935

NM_007668

RefSeq (protein)

NP_001157882
NP_004926

NP_031694

Location (UCSC)Chr 7: 151.05 – 151.06 MbChr 5: 24.62 – 24.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago, and it is saliently expressed in post-mitotic central nervous system neurons (CNS).

The molecule belongs to the cyclin-dependent kinase family. Kinases are enzymes that catalyze reactions of phosphorylation. This process allows the substrate to gain a phosphate group donated by an organic compound known as ATP.  Phosphorylations are of vital importance during glycolysis, therefore, making kinases an essential part of the cell due to their role in the metabolism, cell signaling, and many other processes.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164885Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028969Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.