Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.[5][6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins.[7] The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4.[8] CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression in the point of regulation named R or restriction point.[9]
This kinase is a catalytic subunit of the protein kinase complex, important for the G1 phase progression and G1/S transition of the cell cycle and the complex is composed also by an activating sub-unit; the cyclin D.[10] The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors.[7] This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor Retinoblastoma protein making CDK6 an important protein in cancer development.[10]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000105810 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040274 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, et al. (August 1992). "A family of human cdc2-related protein kinases". The EMBO Journal. 11 (8): 2909–2917. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
- ^ "Entrez Gene: CDK6 cyclin-dependent kinase 6".
- ^ a b Cite error: The named reference
Meyersonwas invoked but never defined (see the help page). - ^ Kumar V, Abbas AK, Aster JC, Robbins SL (2013). Robbins Basic Pathology. ClinicalKey 2012 (9th ed.). Elsevier/Saunders. ISBN 978-1-4377-1781-5.
- ^ Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A, Cascante M (May 2013). "Targeting cell cycle regulation in cancer therapy". Pharmacology & Therapeutics. 138 (2): 255–271. doi:10.1016/j.pharmthera.2013.01.011. PMID 23356980.
- ^ a b Cite error: The named reference
Shuhuiwas invoked but never defined (see the help page).