Cyclin-dependent kinase 9

CDK9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BLH, 3BLQ, 3BLR, 3LQ5, 3MI9, 3MIA, 3MY1, 3TN8, 3TNH, 3TNI, 4BCF, 4BCG, 4BCH, 4BCI, 4BCJ, 4EC8, 4EC9, 4IMY, 4OGR, 4OR5
Identifiers
Aliases	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK, cyclin-dependent kinase 9, cyclin dependent kinase 9
External IDs	OMIM: 603251; MGI: 1328368; HomoloGene: 55566; GeneCards: CDK9; OMA:CDK9 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,790,792 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,603,088 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left ovary; ; right ovary; ; sural nerve; ; left uterine tube; ; gastric mucosa; ; right hemisphere of cerebellum; ; anterior pituitary; ; body of uterus; ; canal of the cervix;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; superior frontal gyrus; ; thymus; ; fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; primary visual cortex; ; dermis; ; epiblast; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; transferase activity; protein kinase activity; 7SK snRNA binding; transcription coactivator binding; snRNA binding; ATP binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA binding; transcription factor binding; protein binding; protein serine/threonine kinase activity; chromatin binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; protein kinase binding; cyclin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; nucleus; membrane; nucleoplasm; transcription elongation factor complex; cyclin/CDK positive transcription elongation factor complex; PML body; chromosome; cytoplasmic ribonucleoprotein granule; cyclin-dependent protein kinase holoenzyme complex;
Biological process	positive regulation of cardiac muscle hypertrophy; positive regulation of mRNA 3'-UTR binding; regulation of muscle cell differentiation; negative regulation of mRNA polyadenylation; DNA repair; cellular response to cytokine stimulus; positive regulation of viral transcription; replication fork processing; protein phosphorylation; regulation of histone modification; regulation of mitotic cell cycle; cellular response to DNA damage stimulus; transcription initiation from RNA polymerase II promoter; regulation of DNA repair; regulation of transcription, DNA-templated; cell population proliferation; transcription by RNA polymerase II; phosphorylation; positive regulation of histone H2B ubiquitination; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; snRNA transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	1025
	107951
	ENSG00000136807
	ENSMUSG00000009555
	P50750
	Q99J95
	NM_001261
	NM_130860
	NP_001252; NP_001252.1
	NP_570930
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009555 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009555 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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