| Cyclin-dependent kinase inhibitor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | CDI | ||||||||||
| Pfam | PF02234 | ||||||||||
| InterPro | IPR003175 | ||||||||||
| SCOP2 | 1jsu / SCOPe / SUPFAM | ||||||||||
| |||||||||||
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as tumor suppressors. Cell cycle progression is stopped by Cyclin-dependent kinase inhibitor protein at the G1 phase.[2] CKIs are vital proteins within the control system that point out whether the processes of DNA synthesis, mitosis, and cytokines control one another. When a malfunction hinders the successful completion of DNA synthesis in the G1 phase, it triggers a signal that delays or halts the progression to the S phase. Cyclin-dependent kinase inhibitor proteins are essential in the regulation of the cell cycle. If cell mutations surpass the cell cycle checkpoints during cell cycle regulation, it can result in various types of cancer.[3]
- ^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–331. Bibcode:1996Natur.382..325R. doi:10.1038/382325a0. PMID 8684460. S2CID 4284942.
- ^ Lim S, Kaldis P (August 2013). "Cdks, cyclins and CKIs: roles beyond cell cycle regulation". Development. 140 (15): 3079–3093. doi:10.1242/dev.091744. PMID 23861057. S2CID 285340.
- ^ Yang VW (2018). "The Cell Cycle". Physiology of the Gastrointestinal Tract. Elsevier. pp. 197–219. doi:10.1016/b978-0-12-809954-4.00008-6. ISBN 978-0-12-809954-4. Retrieved 2023-05-02.