Cyclin A

cyclin A1
Identifiers
SymbolCCNA1
NCBI gene8900
HGNC1577
OMIM604036
RefSeqNM_003914
UniProtP78396
Other data
LocusChr. 13 q12.3-q13
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StructuresSwiss-model
DomainsInterPro
cyclin A2
Identifiers
SymbolCCNA2
Alt. symbolsCCNA, CCN1
NCBI gene890
HGNC1578
OMIM123835
RefSeqNM_001237
UniProtP20248
Other data
LocusChr. 4 q27
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StructuresSwiss-model
DomainsInterPro

Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle.[1] The stages that a cell passes through that culminate in its division and replication are collectively known as the cell cycle[2] Since the successful division and replication of a cell is essential for its survival, the cell cycle is tightly regulated by several components to ensure the efficient and error-free progression through the cell cycle. One such regulatory component is cyclin A which plays a role in the regulation of two different cell cycle stages.[1][3]

  1. ^ a b Bendris N, Lemmers B, Blanchard JM, Arsic N (2011). "Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements". PLOS ONE. 6 (7): e22879. Bibcode:2011PLoSO...622879B. doi:10.1371/journal.pone.0022879. PMC 3145769. PMID 21829545.
  2. ^ Weinberg RE (2007). The biology of cancer. New York: Garland Science. ISBN 978-0-8153-4076-8.
  3. ^ Henglein B, Chenivesse X, Wang J, Eick D, Bréchot C (June 1994). "Structure and cell cycle-regulated transcription of the human cyclin A gene". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5490–4. Bibcode:1994PNAS...91.5490H. doi:10.1073/pnas.91.12.5490. PMC 44021. PMID 8202514.