| cyclin B1 | |||||||
|---|---|---|---|---|---|---|---|
 Structure of human cyclin B.[1] | |||||||
| Identifiers | |||||||
| Symbol | CCNB1 | ||||||
| Alt. symbols | CCNB | ||||||
| NCBI gene | 891 | ||||||
| HGNC | 1579 | ||||||
| OMIM | 123836 | ||||||
| RefSeq | NM_031966 | ||||||
| UniProt | P14635 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q12 | ||||||
| |||||||
| cyclin B2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNB2 | ||||||
| NCBI gene | 9133 | ||||||
| HGNC | 1580 | ||||||
| OMIM | 602755 | ||||||
| RefSeq | NM_004701 | ||||||
| UniProt | O95067 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q21.3 | ||||||
| |||||||
| cyclin B3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNB3 | ||||||
| NCBI gene | 85417 | ||||||
| HGNC | 18709 | ||||||
| OMIM | 300456 | ||||||
| RefSeq | NM_033670 | ||||||
| UniProt | Q8WWL7 | ||||||
| Other data | |||||||
| Locus | Chr. X p11 | ||||||
| |||||||
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle[2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present).[3] The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).
- ^ PDB: 2B9R; Petri, E.T.; Errico, A.; Escobedo, L.; Hunt, T. & Basavappa, R. (2007). "The crystal structure of human cyclin B". Cell Cycle. 6 (11): 1342–9. doi:10.4161/cc.6.11.4297. PMID 17495533.
- ^ Ito M (August 2000). "Factors controlling cyclin B expression" (PDF). Plant Mol. Biol. 43 (5–6): 677–90. doi:10.1023/A:1006336005587. PMID 11089869. S2CID 19593310.[permanent dead link]
- ^ Hershko A (September 1999). "Mechanisms and regulation of the degradation of cyclin B". Philos. Trans. R. Soc. Lond. B Biol. Sci. 354 (1389): 1571–5, discussion 1575–6. doi:10.1098/rstb.1999.0500. PMC 1692665. PMID 10582242.