Cyclin D2

CCND2
Identifiers
Aliases	CCND2, KIAK0002, MPPH3, cyclin D2
External IDs	OMIM: 123833; MGI: 88314; HomoloGene: 37525; GeneCards: CCND2; OMA:CCND2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,305,353 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	127,152,193 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; tail of epididymis; ; ventricular zone; ; ganglionic eminence; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; corpus epididymis; ; epithelium of colon; ; caput epididymis; ; tendon of biceps brachii;
	Top expressed in
	Rostral migratory stream; ; calvaria; ; medial ganglionic eminence; ; hand; ; otic placode; ; vas deferens; ; hair follicle; ; maxillary prominence; ; Paneth cell; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity;
Cellular component	cytoplasm; cytosol; chromatin; cyclin-dependent protein kinase holoenzyme complex; nuclear membrane; nucleolus; membrane; nucleus; nucleoplasm; cyclin D2-CDK4 complex;
Biological process	cell cycle; positive regulation of protein phosphorylation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of cell cycle; cell division; positive regulation of cell population proliferation; positive regulation of G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; long-term memory; adult locomotory behavior; cellular response to X-ray; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle; protein phosphorylation; regulation of mitotic nuclear division; positive regulation of cell cycle; mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	894
	12444
	ENSG00000118971
	ENSMUSG00000000184
	P30279
	P30280
	NM_001759
	NM_009829
	NP_001750
	NP_033959
	Wikidata
View/Edit Human	View/Edit Mouse

G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118971 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (Jul 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118971 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000184 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1386335-5] Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (Jul 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–74. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.

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