Cyclin E/Cdk2

Cyclin E/Cdk2 activity levels throughout the cell cycle.

The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes, the cyclin E/Cdk2 dimer plays a crucial role in regulating the cell cycle, with this specific complex peaking in activity during the G1/S transition.[1] Once the two cyclin and Cdk subunits are joined together, the complex becomes activated and proceeds to phosphorylate and bind to downstream proteins to ultimately promote cell cycle progression. Although cyclin E can bind to other Cdk proteins, its primary binding partner is Cdk2, and the majority of cyclin E activity occurs when it exists as the cyclin E/Cdk2 complex.[2]

  1. ^ Ohtsubo, Motoaki; Theodoras, Anne M.; Schumacher, Jill; Roberts, James M.; Pagano, Michele (1995-05-01). "Human Cyclin E, a Nuclear Protein Essential for the G 1 -to-S Phase Transition". Molecular and Cellular Biology. 15 (5): 2612–2624. doi:10.1128/MCB.15.5.2612. ISSN 1098-5549. PMC 230491. PMID 7739542.
  2. ^ Cite error: The named reference :2 was invoked but never defined (see the help page).