Cyclin E1

CCNE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W98
Identifiers
Aliases	CCNE1, CCNE, pcyclin E1
External IDs	OMIM: 123837; MGI: 88316; HomoloGene: 14452; GeneCards: CCNE1; OMA:CCNE1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	29,824,312 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	37,806,959 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; placenta; ; testicle; ; decidua; ; bone marrow; ; left testis; ; right testis; ; amniotic fluid; ; gingival epithelium; ; mucosa of transverse colon;
	Top expressed in
	embryo; ; epiblast; ; morula; ; condyle; ; fossa; ; internal carotid artery; ; fetal liver hematopoietic progenitor cell; ; primitive streak; ; embryo; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; androgen receptor binding; protein kinase binding; cyclin-dependent protein serine/threonine kinase activity; protein kinase activity;
Cellular component	cytosol; cyclin-dependent protein kinase holoenzyme complex; nucleoplasm; nucleus; cyclin E1-CDK2 complex; cytoplasm; centrosome;
Biological process	androgen receptor signaling pathway; Wnt signaling pathway; regulation of transcription involved in G1/S transition of mitotic cell cycle; regulation of cell cycle; cell division; positive regulation of transcription, DNA-templated; protein phosphorylation; DNA replication initiation; cell cycle; regulation of protein kinase activity; negative regulation of transcription by RNA polymerase II; telomere maintenance; homologous chromosome pairing at meiosis; chromosome organization involved in meiotic cell cycle; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle; regulation of mitotic nuclear division; positive regulation of cell population proliferation; positive regulation of cell cycle; positive regulation of G1/S transition of mitotic cell cycle; mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	898
	12447
	ENSG00000105173
	ENSMUSG00000002068
	P24864
	Q61457
	NM_001238; NM_057182; NM_001322259; NM_001322261; NM_001322262
	NM_007633
NP_001229; NP_001309188; NP_001309190; NP_001309191; NP_001309188.1;
	NP_001309190.1
	NP_031659
	Wikidata
View/Edit Human	View/Edit Mouse

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105173 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002068 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105173 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002068 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1833066-5] Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. S2CID 12166415.

[1]

[2]

[3]

[4]

[5]