Cyclin H

CCNH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JKW, 1KXU
Identifiers
Aliases	CCNH, CAK, CycH, p34, p37, Cyclin H
External IDs	OMIM: 601953; MGI: 1913921; HomoloGene: 946; GeneCards: CCNH; OMA:CCNH - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	87,412,930 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	85,371,588 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; left testis; ; right testis; ; ventricular zone; ; epithelium of colon; ; ganglionic eminence; ; anterior pituitary; ; right lung; ; sperm; ; C1 segment;
	Top expressed in
	interventricular septum; ; fossa; ; condyle; ; endothelial cell of lymphatic vessel; ; vas deferens; ; primitive streak; ; facial motor nucleus; ; otic placode; ; efferent ductule; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATP-dependent activity, acting on DNA; kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity;
Cellular component	nucleoplasm; transcription factor TFIIH holo complex; transcription factor TFIIK complex; nucleus; cyclin-dependent protein kinase activating kinase holoenzyme complex; cyclin-dependent protein kinase holoenzyme complex;
Biological process	termination of RNA polymerase I transcription; regulation of transcription, DNA-templated; phosphorylation; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of phosphorylation of RNA polymerase II C-terminal domain; positive regulation of cyclin-dependent protein serine/threonine kinase activity; cell cycle; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; protein phosphorylation; nucleotide-excision repair, preincision complex assembly; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription by RNA polymerase II; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	902
	66671
	ENSG00000134480
	ENSMUSG00000021548
	P51946
	Q61458
	NM_001199189; NM_001239; NM_001363539; NM_001364075; NM_001364076
	NM_023243; NM_001347587; NM_001347588
	NP_001186118; NP_001230; NP_001350468; NP_001351004; NP_001351005
	NP_001334516; NP_001334517; NP_075732
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-H is a protein that in humans is encoded by the CCNH gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134480 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021548 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (Jan 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics. 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303.
^ "Entrez Gene: CCNH cyclin H".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134480 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021548 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9465303-5] Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (Jan 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics. 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303.

[entrez-6] "Entrez Gene: CCNH cyclin H".

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