Cysteine protease ATG4A

ATG4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P82
Identifiers
Aliases	ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
External IDs	OMIM: 300663; MGI: 2147903; HomoloGene: 70873; GeneCards: ATG4A; OMA:ATG4A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	108,154,671 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	141,164,270 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gastrocnemius muscle; ; muscle of thigh; ; rectum; ; islet of Langerhans; ; tibialis anterior muscle; ; anterior pituitary; ; left ventricle; ; deltoid muscle; ; right lung;
	Top expressed in
	bone marrow; ; quadriceps femoris muscle; ; muscle of thigh; ; proximal tubule; ; muscle tissue; ; right kidney; ; skeletal muscle tissue; ; ileum; ; granulocyte; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; protein binding; hydrolase activity; cysteine-type endopeptidase activity;
Cellular component	cytoplasm; cytosol;
Biological process	autophagy; protein transport; autophagy of nucleus; C-terminal protein lipidation; protein delipidation; autophagy of mitochondrion; autophagosome assembly; proteolysis; protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	115201
	666468
	ENSG00000101844
	ENSMUSG00000079418
	Q8WYN0
	Q8C9S8
NM_052936; NM_178270; NM_178271; NM_001321287; NM_001321288;
	NM_001321289; NM_001321290
	NM_174875
NP_001308216; NP_001308217; NP_001308218; NP_001308219; NP_443168;
	NP_840054; NP_840055
	NP_777364; NP_001366610; NP_001366611; NP_001366612; NP_001366613
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.^[5]^[6]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101844 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
^ ^a ^b "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101844 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079418 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12473658-5] Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.

[entrez-6] "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".

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