Cysteinyl leukotriene receptor 1

CYSLTR1
Identifiers
Aliases	CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81, cysteinyl leukotriene receptor 1
External IDs	OMIM: 300201; MGI: 1926218; HomoloGene: 4837; GeneCards: CYSLTR1; OMA:CYSLTR1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,271,468 bp[1] End 78,327,691 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 105,617,952 bp[2] End 105,647,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell monocyte testicle superficial temporal artery granulocyte bone marrow lymph node blood palpebral conjunctiva Achilles tendon Top expressed in embryo sciatic nerve carotid body embryo skin of external ear stroma of bone marrow muscle of thigh mucosa of small intestine ankle Epithelium of choroid plexus More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled peptide receptor activity G protein-coupled receptor activity leukotriene receptor activity signal transducer activity protein binding galanin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process defense response positive regulation of cytosolic calcium ion concentration respiratory gaseous exchange by respiratory system chemotaxis phospholipase C-activating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway leukotriene signaling pathway circulatory system process neuropeptide signaling pathway calcium ion transport signal transduction inflammatory response to antigenic stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10800 58861 Ensembl ENSG00000173198 ENSMUSG00000052821 UniProt Q9Y271 Q99JA4 RefSeq (mRNA) NM_006639 NM_001282186 NM_001282187 NM_001282188 NM_001281859 NM_001281862 NM_021476 RefSeq (protein) NP_001269115 NP_001269116 NP_001269117 NP_006630 NP_001268788 NP_001268791 NP_067451 Location (UCSC) Chr X: 78.27 – 78.33 Mb Chr X: 105.62 – 105.65 Mb PubMed search [3] [4]
Wikidata
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Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT) (see cysteinyl leukotrienes). CYSLTR1, by binding these cysteinyl LTs (CysLTs; viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans as well as models of the reactions in other animals.