Cysteinyl leukotriene receptor 2

CYSLTR2
Identifiers
AliasesCYSLTR2, CYSLT2, CYSLT2R, HG57, HPN321, KPG_011, hGPCR21, GPCR21, PSEC0146, cysteinyl leukotriene receptor 2
External IDsOMIM: 605666; MGI: 1917336; HomoloGene: 10688; GeneCards: CYSLTR2; OMA:CYSLTR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001162412
NM_133720

RefSeq (protein)

NP_001155884
NP_598481

Location (UCSC)Chr 13: 48.65 – 48.71 MbChr 14: 73.26 – 73.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteinyl leukotriene receptor 2, also termed CYSLTR2, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes#Cysteinyl leukotrienes). CYSLTR2, by binding these cysteinyl LTs (CysLTs; viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans. However, the first discovered receptor for these CsLTs, cysteinyl leukotriene receptor 1 (CysLTR1), appears to play the major role in mediating these reactions.[5][6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152207Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033470Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, Masuho Y, Isogai T, Suzuki Y, Sugano S, Furuichi K (August 2000). "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor". Biochem Biophys Res Commun. 274 (2): 316–22. doi:10.1006/bbrc.2000.3140. PMID 10913337.
  6. ^ Van Keer C, Kersters K, De Ley J (September 1976). "L-Sorbose metabolism in Agrobacterium tumefaciens". Antonie van Leeuwenhoek. 42 (1–2): 13–24. doi:10.1007/BF00399445. PMID 1085123. S2CID 7097419.
  7. ^ "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2".