Cytochrome b-245, alpha polypeptide

CYBA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WLP
Identifiers
Aliases	CYBA, p22-PHOX, Cytochrome b-245, alpha polypeptide, cytochrome b-245 alpha chain, CGD4
External IDs	OMIM: 608508; MGI: 1316658; HomoloGene: 80; GeneCards: CYBA; OMA:CYBA - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 88,643,275 bp[1] End 88,651,083 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 123,151,515 bp[2] End 123,159,669 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon spleen bone marrow right lung right uterine tube upper lobe of left lung bone marrow cells olfactory zone of nasal mucosa Top expressed in granulocyte right kidney mesenteric lymph nodes human kidney tibiofemoral joint spleen stroma of bone marrow yolk sac proximal tubule thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding metal ion binding protein binding heme binding protein heterodimerization activity electron transfer activity oxidoreductase activity superoxide-generating NAD(P)H oxidase activity Cellular component cytoplasm endosome phagocytic vesicle membrane Golgi apparatus membrane plasma membrane perinuclear endoplasmic reticulum secretory granule soma NADPH oxidase complex dendrite apical plasma membrane mitochondrion nucleus endoplasmic reticulum membrane stress fiber focal adhesion specific granule membrane tertiary granule membrane Biological process positive regulation of reactive oxygen species biosynthetic process cellular response to organic substance positive regulation of phagocytosis cytochrome complex assembly response to interleukin-1 positive regulation of endothelial cell proliferation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of release of sequestered calcium ion into cytosol cellular response to tumor necrosis factor cellular response to organic cyclic compound negative regulation of glomerular filtration by angiotensin smooth muscle hypertrophy positive regulation of defense response to bacterium cell redox homeostasis reactive oxygen species metabolic process superoxide anion generation respiratory burst regulation of blood pressure cellular response to mechanical stimulus positive regulation of cell growth vascular endothelial growth factor receptor signaling pathway response to nutrient levels cellular response to gamma radiation positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production cellular response to amino acid stimulus hydrogen peroxide biosynthetic process positive regulation of toll-like receptor 2 signaling pathway positive regulation of superoxide anion generation innate immune response inflammatory response positive regulation of mucus secretion cellular response to glucose stimulus superoxide metabolic process positive regulation of smooth muscle cell proliferation response to aldosterone positive regulation of NAD(P)H oxidase activity cellular response to L-glutamine response to hypoxia cellular response to angiotensin response to activity neutrophil degranulation cellular response to oxidative stress electron transport chain positive regulation of blood pressure Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1535 13057 Ensembl ENSG00000051523 ENSMUSG00000006519 UniProt P13498 Q61462 RefSeq (mRNA) NM_000101 NM_001301284 NM_007806 RefSeq (protein) NP_000092 NP_001288213 NP_031832 Location (UCSC) Chr 16: 88.64 – 88.65 Mb Chr 8: 123.15 – 123.16 Mb PubMed search [3] [4]
Wikidata
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Cytochrome b-245 light chain is a protein that in humans is encoded by the CYBA gene involved in superoxide production and phagocytosis.^[5]

Cytochrome b-245 is composed of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit, which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), which is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.^[6]