| 3-deoxy-7-phosphoheptulonate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.54 | ||||||||
| CAS no. | 9026-94-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| DAHP synthetase I domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of Aquifex aeolicus kdo8ps in complex with z-methyl-pep 2-dehydro-3-deoxyphosphooctonate aldolase.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | DAHP_synth_1 | ||||||||
| Pfam | PF00793 | ||||||||
| Pfam clan | CL0036 | ||||||||
| InterPro | IPR006218 | ||||||||
| SCOP2 | 51569 / SCOPe / SUPFAM | ||||||||
| |||||||||
3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase (EC 2.5.1.54) is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. Since it is the first enzyme in the shikimate pathway, it controls the amount of carbon entering the pathway. Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway.[2] Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme.
In enzymology, a DAHP synthase (EC 2.5.1.54) is an enzyme that catalyzes the chemical reaction
- phosphoenolpyruvate + D-erythrose 4-phosphate + H2O 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate
The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H2O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate.
- ^ Xu X, Wang J, Grison C, Petek S, Coutrot P, Birck MR, Woodard RW, Gatti DL (2003). "Structure-based design of novel inhibitors of 3-deoxy-D-manno-octulosonate 8-phosphate synthase". Drug Design and Discovery. 18 (2–3): 91–9. doi:10.3109/10559610290271787. PMID 14675946.
- ^ Herrmann K, Entus R (2001). "Shikimate Pathway: Aromatic Amino Acids and Beyond". Encyclopedia of Life Sciences. doi:10.1038/npg.els.0001315. ISBN 978-0-470-01617-6.