DBP (gene)

DBP
Identifiers
Aliases	DBP, DABP, D-box binding PAR bZIP transcription factor, taxREB302
External IDs	OMIM: 124097; MGI: 94866; HomoloGene: 1035; GeneCards: DBP; OMA:DBP - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,637,379 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,359,627 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right adrenal cortex; ; right frontal lobe; ; caudate nucleus; ; nucleus accumbens; ; prefrontal cortex; ; putamen; ; left adrenal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	retinal pigment epithelium; ; Epithelium of choroid plexus; ; iris; ; olfactory tubercle; ; ankle; ; vestibular membrane of cochlear duct; ; nucleus accumbens; ; lacrimal gland; ; suprachiasmatic nucleus; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription by RNA polymerase II; liver development; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; circadian rhythm; multicellular organism development; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1628
	13170
	ENSG00000105516
	ENSMUSG00000059824
	Q10586
	Q60925
	NM_001352
	NM_016974
	NP_001343
	NP_058670
	Wikidata
View/Edit Human	View/Edit Mouse

D site of albumin promoter (albumin D-box) binding protein, also known as DBP, is a protein which in humans is encoded by the DBP gene.^[5]^[6]

DBP is a member of the PAR bZIP (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family.^[5]^[7] DBP binds to an upstream promoter in the insulin gene.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105516 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059824 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: DBP D site of albumin promoter (albumin D-box) binding protein".
^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jun 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
^ Khatib ZA, Inaba T, Valentine M, Look AT (Sep 1994). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.
^ Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia. 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105516 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059824 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DBP D site of albumin promoter (albumin D-box) binding protein".

[pmid1535333-6] Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jun 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.

[pmid7835883-7] Khatib ZA, Inaba T, Valentine M, Look AT (Sep 1994). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.

[pmid11914736-8] Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia. 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736.

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