DBX2

DBX2
Identifiers
AliasesDBX2, developing brain homeobox 2
External IDsMGI: 107445; HomoloGene: 54981; GeneCards: DBX2; OMA:DBX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001004329

NM_207533

RefSeq (protein)

NP_001004329

n/a

Location (UCSC)Chr 12: 45.01 – 45.05 MbChr 15: 95.52 – 95.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene.[5][6] DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain.[7] The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185610Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045608Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: developing brain homeobox 2".
  6. ^ Pierani A, Moran-Rivard L, Sunshine MJ, Littman DR, Goulding M, Jessell TM (February 2001). "Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1". Neuron. 29 (2): 367–384. doi:10.1016/S0896-6273(01)00212-4. PMID 11239429. S2CID 2647092.
  7. ^ Ma P, Zhao S, Zeng W, Yang Q, Li C, Lv X, et al. (August 2011). "Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning". Biochemical and Biophysical Research Communications. 412 (1): 170–174. doi:10.1016/j.bbrc.2011.07.068. PMID 21806971.
  8. ^ "DBX2 Gene - GeneCards | DBX2 Protein | DBX2 Antibody". www.genecards.org. Retrieved 2022-04-01.