Clinical data | |
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Other names | Dodecyl 2-N,N-dimethylaminopropionate; Dodecyl-2-(dimethylamino)propionate; N,N-Dimethylalanine dodecyl ester |
Pharmacokinetic data | |
Bioavailability | <1% (topical) |
Protein binding | >99% |
Metabolism | Esterase mediated |
Elimination half-life | 5 hours |
Excretion | Urinary |
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CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C17H36ClNO2 |
Molar mass | 321.93 g·mol−1 |
3D model (JSmol) | |
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DDAIP is a pharmaceutical ingredient added to topical products to increase penetration through the skin. Chemically, DDAIP is an ester of N,N-dimethylalanine and dodecanol, although as of now the structural formula shows an ester with decanol (C10) instead. DDAIP is typically formulated as its hydrochloride salt (DDAIP.HCl). This salt is a white crystalline solid with a melting range of 88-93 °C and is an amphiphilic molecule with a pKa of 4.87 that is soluble in water up to about 40% w/v. DDAIP is proprietary to NexMed USA, a subsidiary of Apricus Biosciences.[1]