| DEAD/DEAH box helicase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| Symbol | DEAD | ||||||||
| Pfam | PF00270 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR011545 | ||||||||
| PROSITE | PDOC00039 | ||||||||
| SCOP2 | 1qva / SCOPe / SUPFAM | ||||||||
| CDD | cd00268 | ||||||||
| |||||||||
DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids.[2] They are highly conserved in nine motifs and can be found in most prokaryotes and eukaryotes, but not all. Many organisms, including humans, contain DEAD-box (SF2) helicases, which are involved in RNA metabolism.[3]
- ^ Johnson, E. R.; McKay, D. B. (1999). "Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase". RNA. 5 (12): 1526–1534. doi:10.1017/S1355838299991410. PMC 1369875. PMID 10606264.
- ^ Takashi Kikuma; Masaya Ohtsu; Takahiko Utsugi; Shoko Koga; Kohji Okuhara; Toshihiko Eki; Fumihiro Fujimori; Yasufumi Murakami (March 2004). "Dbp9p, a Member of the DEAD Box Protein Family, Exhibits DNA Helicase Activity". J. Biol. Chem. 279 (20): 20692–20698. doi:10.1074/jbc.M400231200. PMID 15028736.
- ^ Heung LJ, Del Poeta M (March 2005). "Unlocking the DEAD-box: a key to cryptococcal virulence?". J. Clin. Invest. 115 (3): 593–5. doi:10.1172/JCI24508. PMC 1052016. PMID 15765144.