DEFA1

DEFA1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2KHT, 2PM1, 3GNY, 3H6C, 3HJ2, 3HJD, 3LO1, 3LO2, 3LO4, 3LO6, 3LO9, 3LOE, 3LVX, 4DU0, 4LB1, 4LB7, 4LBB, 4LBF
Identifiers
Aliases	DEFA1, DEF1, DEFA2, HNP-1, HP-1, HP1, MRS, defensin alpha 1
External IDs	OMIM: 125220; HomoloGene: 128756; GeneCards: DEFA1; OMA:DEFA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,980,092 bp
RNA expression pattern
	Top expressed in
	right lung; ; granulocyte; ; monocyte; ; blood; ; bone marrow; ; spleen; ; bone marrow cells; ; upper lobe of left lung; ; Descending thoracic aorta; ; placenta;
	n/a
	More reference expression data
	More reference expression data
Orthologs
	1667
	n/a
	ENSG00000206047; ENSG00000284983
	n/a
	P59665
	n/a
	NM_004084
	n/a
	NP_001035965; NP_001289194
	n/a
	Wikidata
View/Edit Human

Defensin, alpha 1 also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1 gene.^[3]^[4]^[5] Human alpha defensin 1 belongs to the alpha defensin family of antimicrobial peptides.

^ ^a ^b ^c ENSG00000284983 GRCh38: Ensembl release 89: ENSG00000206047, ENSG00000284983 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM (Mar 1997). "Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes". J Neurosci. 17 (5): 1539–47. doi:10.1523/JNEUROSCI.17-05-01539.1997. PMC 6573369. PMID 9030614.
^ Aldred PM, Hollox EJ, Armour JA (Jul 2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3". Hum Mol Genet. 14 (14): 2045–52. doi:10.1093/hmg/ddi209. PMID 15944200.
^ "Entrez Gene: DEFA1 defensin, alpha 1".

[refGRCh38Ensembl-1] ENSG00000284983 GRCh38: Ensembl release 89: ENSG00000206047, ENSG00000284983 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9030614-3] Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM (Mar 1997). "Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes". J Neurosci. 17 (5): 1539–47. doi:10.1523/JNEUROSCI.17-05-01539.1997. PMC 6573369. PMID 9030614.

[pmid15944200-4] Aldred PM, Hollox EJ, Armour JA (Jul 2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3". Hum Mol Genet. 14 (14): 2045–52. doi:10.1093/hmg/ddi209. PMID 15944200.

[entrez-5] "Entrez Gene: DEFA1 defensin, alpha 1".

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