DLG4

DLG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KEF, 3I4W, 3K82, 3ZRT
Identifiers
Aliases	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
External IDs	OMIM: 602887; MGI: 1277959; HomoloGene: 1047; GeneCards: DLG4; OMA:DLG4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,187,187 bp[1] End 7,219,841 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,907,768 bp[2] End 69,938,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe nucleus accumbens cingulate gyrus anterior cingulate cortex prefrontal cortex anterior pituitary Brodmann area 9 amygdala caudate nucleus Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex CA3 field tail of embryo perirhinal cortex cerebellar cortex entorhinal cortex genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-1 adrenergic receptor binding PDZ domain binding protein-containing complex binding scaffold protein binding guanylate kinase activity P2Y1 nucleotide receptor binding acetylcholine receptor binding kinase binding protein C-terminus binding protein binding ionotropic glutamate receptor binding D1 dopamine receptor binding protein phosphatase binding neuroligin family protein binding ligand-gated ion channel activity Cellular component cytoplasm juxtaparanode region of axon endocytic vesicle membrane synaptic membrane postsynaptic membrane cell projection membrane postsynaptic density synaptic vesicle extrinsic component of cytoplasmic side of plasma membrane voltage-gated potassium channel complex cortical cytoskeleton plasma membrane dendritic spine synapse excitatory synapse cerebellar mossy fiber axon cell junction dendrite basolateral plasma membrane endoplasmic reticulum neuron spine AMPA glutamate receptor complex dendrite cytoplasm ionotropic glutamate receptor complex neuron projection terminus cell periphery cytosol postsynaptic density membrane postsynapse neuromuscular junction neuron projection glutamatergic synapse Biological process receptor localization to synapse regulation of grooming behavior regulation of long-term neuronal synaptic plasticity neuromuscular process controlling balance negative regulation of receptor internalization establishment of protein localization positive regulation of cytosolic calcium ion concentration learning nervous system development MAPK cascade locomotory exploration behavior regulation of NMDA receptor activity AMPA glutamate receptor clustering dendritic spine morphogenesis vocalization behavior positive regulation of synaptic transmission establishment or maintenance of epithelial cell apical/basal polarity positive regulation of excitatory postsynaptic potential social behavior synaptic vesicle maturation protein localization to synapse signal transduction GMP metabolic process GDP metabolic process chemical synaptic transmission transmembrane transport cellular response to potassium ion receptor clustering positive regulation of protein tyrosine kinase activity protein-containing complex assembly cell-cell adhesion postsynaptic neurotransmitter receptor diffusion trapping positive regulation of neuron projection arborization neurotransmitter receptor localization to postsynaptic specialization membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1742 13385 Ensembl ENSG00000132535 ENSMUSG00000020886 UniProt P78352 O14909 Q62108 RefSeq (mRNA) NM_001128827 NM_001365 NM_001321074 NM_001321075 NM_001321076 NM_001321077 NM_001369566 NM_001109752 NM_007864 NM_001370671 NM_001370672 NM_001370674 NM_001370675 RefSeq (protein) NP_001122299 NP_001308003 NP_001308004 NP_001308005 NP_001308006 NP_001356 NP_001103222 NP_031890 Location (UCSC) Chr 17: 7.19 – 7.22 Mb Chr 11: 69.91 – 69.94 Mb PubMed search [3] [4]
Wikidata
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PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.^[5][6][7]

PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.^[5] PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons,^[8] and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.^[9] It plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.^[10]