DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.[5][6][7] Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138346 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036875 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–10. doi:10.1006/geno.1996.0581. PMID 8938459.
- ^ Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". J Biol Chem. 281 (50): 38555–64. doi:10.1074/jbc.M604925200. PMID 17032657.
- ^ "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".
- ^ Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.