DNAH9

DNAH9
Identifiers
Aliases	DNAH9, DNAH17L, DNEL1, DYH9, Dnahc9, HL-20, HL20, dynein axonemal heavy chain 9, CILD40
External IDs	OMIM: 603330; MGI: 1289279; HomoloGene: 20357; GeneCards: DNAH9; OMA:DNAH9 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	11,969,748 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	66,059,377 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; epithelium of nasopharynx; ; C1 segment; ; sperm; ; testicle; ; caudate nucleus; ; secondary oocyte;
	Top expressed in
	choroidal fissure; ; zygote; ; secondary oocyte; ; choroid plexus of fourth ventricle; ; olfactory epithelium; ; primary oocyte; ; Epithelium of choroid plexus; ; embryo; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; ATPase activity; ATP binding; cytoskeletal motor activity; minus-end-directed microtubule motor activity; dynein light chain binding; dynein intermediate chain binding; dynein light intermediate chain binding;
Cellular component	cytoplasm; axoneme; cell projection; cilium; microtubule; cytoskeleton; dynein complex; motile cilium; 9+2 motile cilium; distal portion of axoneme;
Biological process	microtubule-based movement; cell projection organization; cilium movement;
	Sources:Amigo / QuickGO
Orthologs
	1770
	237806
	ENSG00000007174
	ENSMUSG00000056752
	Q9NYC9
	n/a
	NM_001372; NM_004662
	NM_001099633
	NP_001363; NP_004653
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.^[5]^[6]^[7]

This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007174 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
^ Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. hdl:2123/16163. PMID 11247663.
^ ^a ^b "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007174 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812413-5] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

[pmid11247663-6] Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. hdl:2123/16163. PMID 11247663.

[entrez-7] "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

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