DNAJA3

DNAJA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CTT, 2DN9
Identifiers
Aliases	DNAJA3, HCA57, TID1, hTID-1, DnaJ heat shock protein family (Hsp40) member A3
External IDs	OMIM: 608382; MGI: 1933786; HomoloGene: 36170; GeneCards: DNAJA3; OMA:DNAJA3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 4,425,805 bp[1] End 4,456,775 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.46 cM Start 4,457,853 bp[2] End 4,525,559 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue muscle of thigh right adrenal gland right adrenal cortex right lobe of liver left adrenal gland left ventricle left adrenal cortex apex of heart Top expressed in interventricular septum Ileal epithelium extensor digitorum longus muscle brown adipose tissue right kidney plantaris muscle soleus muscle digastric muscle myocardium of ventricle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interferon-gamma receptor binding heat shock protein binding GTPase regulator activity unfolded protein binding transcription factor binding metal ion binding NF-kappaB binding protein binding ATP binding protein kinase binding Hsp70 protein binding Cellular component cytoplasm cytosol postsynaptic membrane I-kappaB/NF-kappaB complex intracellular membrane-bounded organelle membrane neuromuscular junction plasma membrane synapse cell junction mitochondrial matrix mitochondrion actin filament extrinsic component of plasma membrane mitochondrial nucleoid IkappaB kinase complex nucleus Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of interferon-gamma-mediated signaling pathway T cell differentiation in thymus response to interferon-gamma negative regulation of protein kinase activity small GTPase mediated signal transduction protein stabilization mitochondrion organization negative regulation of apoptotic process activation-induced cell death of T cells response to heat negative regulation of transcription by RNA polymerase II mitochondrial DNA replication negative regulation of I-kappaB kinase/NF-kappaB signaling protein folding neuromuscular junction development positive regulation of T cell proliferation positive regulation of apoptotic process negative regulation of programmed cell death regulation of catalytic activity negative regulation of NF-kappaB transcription factor activity activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein ubiquitination negative regulation of cell population proliferation apoptotic process skeletal muscle acetylcholine-gated channel clustering Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9093 83945 Ensembl ENSG00000276726 ENSG00000103423 ENSMUSG00000004069 UniProt Q96EY1 Q53G26 Q99M87 RefSeq (mRNA) NM_005147 NM_001135110 NM_001286516 NM_001135112 NM_023646 RefSeq (protein) NP_001128582 NP_001273445 NP_005138 NP_005138.3 NP_001128584 NP_076135 Location (UCSC) Chr 16: 4.43 – 4.46 Mb Chr 16: 4.46 – 4.53 Mb PubMed search [3] [4]
Wikidata
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DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16.^[5][6][7] This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly.^[6][7][8] As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death.^{[6][7][9][10][11]} Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.^{[7][9][11][12]}