DNASE1L2

DNASE1L2
Identifiers
Aliases	DNASE1L2, DNAS1L2, deoxyribonuclease I-like 2, deoxyribonuclease 1 like 2
External IDs	OMIM: 602622; MGI: 1913955; HomoloGene: 74391; GeneCards: DNASE1L2; OMA:DNASE1L2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,238,711 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,662,079 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; skin of arm; ; right hemisphere of cerebellum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right frontal lobe; ; skin of thigh; ; vulva; ; Brodmann area 9;
	Top expressed in
	lip; ; esophagus; ; transitional epithelium of urinary bladder; ; skin of back; ; skin of external ear; ; umbilical cord; ; neural layer of retina; ; hair follicle; ; granulocyte; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; calcium ion binding; endonuclease activity; nuclease activity; hydrolase activity; deoxyribonuclease activity; metal ion binding; deoxyribonuclease I activity;
Cellular component	cytoplasm; extracellular region; nucleus;
Biological process	hair follicle development; DNA metabolic process; DNA catabolic process; corneocyte development; nucleic acid phosphodiester bond hydrolysis; DNA catabolic process, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	1775
	66705
	ENSG00000167968
	ENSMUSG00000024136
	Q92874
	Q9D1G0
	NM_001301680; NM_001374
	NM_025718
	NP_001288609; NP_001365
	NP_079994
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease-1-like 2 is an enzyme that in humans is encoded by the DNASE1L2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024136 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
^ Germino GG, Weinstat-Saslow D, Himmelbauer H, Gillespie GA, Somlo S, Wirth B, Barton N, Harris KL, Frischauf AM, Reeders ST (Jun 1992). "The gene for autosomal dominant polycystic kidney disease lies in a 750-kb CpG-rich region". Genomics. 13 (1): 144–51. doi:10.1016/0888-7543(92)90214-D. PMID 1577479.
^ "Entrez Gene: DNASE1L2 deoxyribonuclease I-like 2".