DNA ligase 1

LIG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X9N
Identifiers
Aliases	LIG1, DNA ligase 1, LIGI, hLig1, IMD96
External IDs	OMIM: 126391; MGI: 101789; HomoloGene: 197; GeneCards: LIG1; OMA:LIG1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,115,445 bp[1] End 48,170,603 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 7.82 cM Start 13,011,239 bp[2] End 13,045,350 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube ventricular zone ganglionic eminence sural nerve mucosa of transverse colon left testis granulocyte gonad right testis testicle Top expressed in tail of embryo genital tubercle outer renal medulla fetal liver hematopoietic progenitor cell inner renal medulla primitive streak epiblast somite yolk sac maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding DNA ligase (ATP) activity metal ion binding ligase activity ATP binding DNA ligase activity Cellular component intracellular membrane-bounded organelle nucleoplasm mitochondrion nucleus cytoplasm Biological process nucleotide-excision repair, DNA gap filling DNA recombination DNA biosynthetic process anatomical structure morphogenesis Okazaki fragment processing involved in mitotic DNA replication cellular response to DNA damage stimulus cell division DNA replication V(D)J recombination DNA mismatch repair DNA ligation involved in DNA repair cell cycle transcription-coupled nucleotide-excision repair DNA repair base-excision repair DNA ligation lagging strand elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3978 16881 Ensembl ENSG00000105486 ENSMUSG00000056394 UniProt P18858 P37913 RefSeq (mRNA) NM_000234 NM_001289063 NM_001289064 NM_001320970 NM_001320971 NM_001083188 NM_001199310 NM_010715 RefSeq (protein) NP_000225 NP_001275992 NP_001275993 NP_001307899 NP_001307900 NP_001076657 NP_001186239 NP_034845 Location (UCSC) Chr 19: 48.12 – 48.17 Mb Chr 7: 13.01 – 13.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.