DNA ligase 3

LIG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IMO, 1IN1, 1UW0, 3L2P, 3PC7, 3PC8, 3QVG
Identifiers
Aliases	LIG3, LIG2, DNA ligase 3, LIG3alpha, MTDPS20
External IDs	OMIM: 600940; MGI: 109152; HomoloGene: 32109; GeneCards: LIG3; OMA:LIG3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,980,512 bp[1] End 35,009,743 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 50.23 cM Start 82,671,934 bp[2] End 82,695,100 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus epithelium of colon ganglionic eminence sural nerve body of uterus right testis left testis ventricular zone right uterine tube Top expressed in gastrula spermatocyte spermatid seminiferous tubule genital tubercle secondary oocyte ventricular zone zygote tail of embryo submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding zinc ion binding metal ion binding ligase activity protein binding DNA ligase activity ATP binding DNA ligase (ATP) activity Cellular component DNA ligase III-XRCC1 complex nucleoplasm nucleus mitochondrion cytoplasm Biological process nucleotide-excision repair, DNA gap filling DNA recombination lagging strand elongation DNA biosynthetic process mitochondrial DNA repair mitochondrion organization double-strand break repair via alternative nonhomologous end joining negative regulation of mitochondrial DNA replication cellular response to DNA damage stimulus cell division DNA ligation DNA replication double-strand break repair via homologous recombination V(D)J recombination DNA ligation involved in DNA repair cell cycle transcription-coupled nucleotide-excision repair double-strand break repair DNA repair base-excision repair, DNA ligation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3980 16882 Ensembl ENSG00000005156 ENSMUSG00000020697 UniProt P49916 P97386 RefSeq (mRNA) NM_002311 NM_013975 NM_001291245 NM_001291246 NM_001291247 NM_010716 RefSeq (protein) NP_002302 NP_039269 n/a Location (UCSC) Chr 17: 34.98 – 35.01 Mb Chr 11: 82.67 – 82.7 Mb PubMed search [3] [4]
Wikidata
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DNA ligase 3 also DNA ligase III, is an enzyme that, in humans, is encoded by the LIG3 gene.^[5][6] LIG3 encodes ATP-dependent DNA ligases that seal interruptions in the phosphodiester backbone of duplex DNA.

There are three families of ATP-dependent DNA ligases in eukaryotes.^[7] These enzymes utilize the same three step reaction mechanism; (i) formation of a covalent enzyme-adenylate intermediate; (ii) transfer of the adenylate group to the 5' phosphate terminus of a DNA nick; (iii) phosphodiester bond formation. Unlike LIG1 and LIG4 family members that are found in almost all eukaryotes, LIG3 family members are less widely distributed.^[8] LIG3 encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below.