DNM1L

DNM1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3W6N, 3W6O, 3W6P, 4BEJ, 4H1U, 4H1V
Identifiers
Aliases	DNM1L, DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV, dynamin 1-like, dynamin 1 like, EMPF1, OPA5
External IDs	OMIM: 603850; MGI: 1921256; HomoloGene: 6384; GeneCards: DNM1L; OMA:DNM1L - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.21 Start 32,679,200 bp[1] End 32,745,650 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A2 Start 16,130,094 bp[2] End 16,176,823 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta sperm pars reticulata Brodmann area 23 external globus pallidus parietal lobe superior vestibular nucleus postcentral gyrus entorhinal cortex Top expressed in ventral tegmental area dorsomedial hypothalamic nucleus habenula dorsal tegmental nucleus pontine nuclei medial geniculate nucleus lateral hypothalamus paraventricular nucleus of hypothalamus lateral geniculate nucleus medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein homodimerization activity GTP binding protein binding GTPase activity identical protein binding hydrolase activity ubiquitin protein ligase binding lipid binding GTPase activator activity GTP-dependent protein binding microtubule binding clathrin binding protein-containing complex binding BH2 domain binding Cellular component cytoplasm cytosol Golgi apparatus membrane intracellular membrane-bounded organelle microtubule cytoskeleton peroxisome synapse synaptic vesicle membrane mitochondrial outer membrane cell junction mitochondrion brush border perinuclear region of cytoplasm clathrin-coated pit microtubule cytoplasmic vesicle endomembrane system endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum mitochondrial membranes protein-containing complex postsynapse presynaptic endocytic zone membrane mitochondrion-derived vesicle secretory vesicle Biological process mitochondrial fragmentation involved in apoptotic process regulation of ATP metabolic process positive regulation of mitochondrial fission endocytosis cellular component disassembly involved in execution phase of apoptosis mitochondrial fission regulation of mitochondrion organization regulation of protein oligomerization regulation of peroxisome organization membrane fusion peroxisome fission regulation of autophagy of mitochondrion positive regulation of protein secretion positive regulation of apoptotic process protein localization to mitochondrion positive regulation of release of cytochrome c from mitochondria necroptosis dynamin family protein polymerization involved in mitochondrial fission heart contraction mitochondrion morphogenesis protein homotetramerization mitochondrial membrane fission positive regulation of intrinsic apoptotic signaling pathway release of cytochrome c from mitochondria positive regulation of GTPase activity protein complex oligomerization programmed cell death mitochondrion organization endoplasmic reticulum organization apoptotic mitochondrial changes negative regulation of mitochondrial fusion synaptic vesicle recycling via endosome intracellular distribution of mitochondria synaptic vesicle endocytosis protein homooligomerization positive regulation of dendritic spine morphogenesis cellular response to lipid cellular response to oxygen-glucose deprivation execution phase of apoptosis positive regulation of synaptic vesicle endocytosis response to flavonoid response to hypobaric hypoxia positive regulation of synaptic vesicle exocytosis calcium ion transport regulation of gene expression regulation of ubiquitin protein ligase activity rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10059 74006 Ensembl ENSG00000087470 ENSMUSG00000022789 UniProt O00429 Q8K1M6 RefSeq (mRNA) NM_001278463 NM_001278464 NM_001278465 NM_001278466 NM_005690 NM_012062 NM_012063 NM_001330380 NM_001025947 NM_001276340 NM_001276341 NM_152816 NM_001360007 NM_001360008 NM_001360009 NM_001360010 RefSeq (protein) NP_001265392 NP_001265393 NP_001265394 NP_001265395 NP_001317309 NP_005681 NP_036192 NP_036193 NP_001021118 NP_001263269 NP_001263270 NP_690029 NP_001346936 NP_001346937 NP_001346938 NP_001346939 NP_001392181 NP_001392182 NP_001392183 NP_001392184 NP_001392185 NP_001392186 NP_001392187 NP_001392188 NP_001392189 NP_001392190 NP_001392191 NP_001392192 NP_001392193 NP_001392194 Location (UCSC) Chr 12: 32.68 – 32.75 Mb Chr 16: 16.13 – 16.18 Mb PubMed search [3] [4]
Wikidata
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Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene and is part of the dynamin superfamily (DSP) family of proteins.^[5][6][7]