DNM2

DNM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YS1
Identifiers
Aliases	DNM2, CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5, dynamin 2
External IDs	OMIM: 602378; MGI: 109547; HomoloGene: 90883; GeneCards: DNM2; OMA:DNM2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,833,488 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,419,055 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; skin of leg; ; right lung; ; upper lobe of left lung; ; rectum; ; skin of abdomen; ; body of stomach; ; apex of heart; ; gastric mucosa;
	Top expressed in
	granulocyte; ; renal corpuscle; ; ankle joint; ; lip; ; ascending aorta; ; tail of embryo; ; aortic valve; ; medullary collecting duct; ; endocardial cushion; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; nitric-oxide synthase binding; SH3 domain binding; phosphatidylinositol 3-kinase regulatory subunit binding; D2 dopamine receptor binding; GTP binding; protein binding; WW domain binding; protein-containing complex binding; enzyme binding; hydrolase activity; protein kinase binding; GTPase activity; microtubule binding;
Cellular component	endocytic vesicle membrane; cytosol; endosome; centrosome; Golgi apparatus; postsynaptic membrane; membrane; postsynaptic density; focal adhesion; photoreceptor inner segment; clathrin-coated endocytic vesicle; Golgi membrane; plasma membrane; synapse; ruffle membrane; cell junction; trans-Golgi network; midbody; growth cone; perinuclear region of cytoplasm; clathrin-coated pit; phagocytic cup; microtubule; extracellular exosome; cytoskeleton; nucleus; lamellipodium; cell projection; cytoplasmic vesicle; phagocytic vesicle membrane; cytoplasm; mitochondrial membranes; axon; protein-containing complex; dendritic spine; dendritic spine head; presynapse; postsynaptic endocytic zone membrane; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	negative regulation of membrane tubulation; G protein-coupled receptor internalization; positive regulation of phagocytosis; neuron projection morphogenesis; regulation of transcription, DNA-templated; endocytosis; regulation of axon extension; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; response to light stimulus; cellular response to X-ray; positive regulation of nitric oxide biosynthetic process; cellular response to dopamine; regulation of nitric-oxide synthase activity; receptor internalization; regulation of Rac protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; receptor-mediated endocytosis; coronary vasculature development; positive regulation of transcription, DNA-templated; positive regulation of P-type sodium:potassium-exchanging transporter activity; aorta development; positive regulation of endocytosis; positive regulation of substrate adhesion-dependent cell spreading; regulation of Golgi organization; G2/M transition of mitotic cell cycle; macropinocytosis; spermatogenesis; positive regulation of apoptotic process; synaptic vesicle transport; cellular response to nitric oxide; positive regulation of lamellipodium assembly; Golgi to plasma membrane transport; cellular response to carbon monoxide; signal transduction; response to cocaine; phagocytosis; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; membrane organization; membrane fusion; negative regulation of non-motile cilium assembly; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; regulation of synapse structure or activity; postsynaptic neurotransmitter receptor internalization; positive regulation of clathrin-dependent endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1785
	13430
	ENSG00000079805
	ENSMUSG00000033335
	P50570
	P39054
	NM_004945; NM_001005360; NM_001005361; NM_001005362; NM_001190716
NM_001039520; NM_001253893; NM_001253894; NM_007871; NM_001357718;
	NM_001357719; NM_001357721
	NP_001005360; NP_001005361; NP_001005362; NP_001177645; NP_004936
NP_001034609; NP_001240822; NP_001240823; NP_031897; NP_001344647;
	NP_001344648; NP_001344650
	Wikidata
View/Edit Human	View/Edit Mouse

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079805 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033335 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G (Nov 1995). "Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family". Gene. 163 (2): 301–6. doi:10.1016/0378-1119(95)00275-B. PMID 7590285.
^ Klocke R, Augustin A, Ronsiek M, Stief A, van der Putten H, Jockusch H (Jul 1997). "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively". Genomics. 41 (2): 290–2. doi:10.1006/geno.1997.4634. PMID 9143510.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079805 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033335 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7590285-5] Diatloff-Zito C, Gordon AJ, Duchaud E, Merlin G (Nov 1995). "Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family". Gene. 163 (2): 301–6. doi:10.1016/0378-1119(95)00275-B. PMID 7590285.

[pmid9143510-6] Klocke R, Augustin A, Ronsiek M, Stief A, van der Putten H, Jockusch H (Jul 1997). "Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively". Genomics. 41 (2): 290–2. doi:10.1006/geno.1997.4634. PMID 9143510.

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