| Dactylosporangium aurantiacum | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Micromonosporales |
| Family: | Micromonosporaceae |
| Genus: | Dactylosporangium |
| Species: | D. aurantiacum
|
| Binomial name | |
| Dactylosporangium aurantiacum Thiemann et al. 1967 (Approved Lists 1980)
| |
| Type strain | |
| ATCC 23491 DSM 43157 IFO 12592 JCM 3083 NBRC 12592 NRRL B-8018 NRRL B-8111 VKM Ac-654 | |
Dactylosporangium aurantiacum is a Gram-positive soil-based actinobacterium in the family Micromonosporaceae.[1] Like all Dactylosporangium species, aurantiacum is aerobic and mesophilic.[2]
One subspecies, hamdenesis, produces a number of 18-membered macrolide antibiotics called tiacumicins as a byproduct of fermentation.[3] One of these, tiacumicin B, commonly known as fidaxomicin,[4] has narrow-spectrum bacteriocidal action against Gram-positive anaerobic bacteria, including Clostridioides difficile.
- ^ Podstawka, Adam. "Dactylosporangium aurantiacum D-748 | Type strain | DSM 43157, ATCC 23491, IFO 12592, IMET 9028, JCM 3083, KCC A-0083, NBRC 12592, RIA 922, BCRC 13312, CBS 621.67, CECT 3288, CGMCC 4.1066, IFM 1208, IMSNU 22001, IMSNU 22064, KCTC 9073, MTCC 500, NCIMB 12887, NRRL B-8018, NRRL B-8111, VKM Ac-654 | BacDiveID:7869". bacdive.dsmz.de.
- ^ Bergey's Manual of Systematic Bacteriology: Volume 5: The Actinobacteria.
- ^ Hochlowski, J. E.; Swanson, S. J.; Ranfranz, L. M.; Whittern, D. N.; Buko, A. M.; McAlpine, J. B. (1987). "Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination". The Journal of Antibiotics. 40 (5): 575–88. doi:10.7164/antibiotics.40.575. PMID 3610816.
- ^ Baktash, A.; Terveer, E. M.; Zwittink, R. D.; Hornung, B. V.; Corver, J.; Kuijper, E. J.; Smits, W. K. (2018). "Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections". Frontiers in Microbiology. 9: 1242. doi:10.3389/fmicb.2018.01242. PMC 6005852. PMID 29946308.