David Hoffman may refer to:
- David Hoffman (jurist) (1784–1854), American jurist
- David Alan Hoffman (born 1947), American attorney
- David Allen Hoffman, American mathematician
- David E. Hoffman (born 1953), American writer and journalist
- David Francis Hoffman (born 1946), American criminal
- David H. Hoffman (born 1967), former federal prosecutor
- David George Hoffman (born 1948), wrongly convicted Canadian man.
- David Lee Hoffman, American importer and inventor
- David M. Hoffman (born 1945), American author, political commentator and media activist