David Willis may refer to:
- David Willis (English footballer) (1881–1949), English footballer for Sunderland, Newcastle United, and Reading
- David Willis (cartoonist) (born 1979), web cartoonist
- David Willis (journalist) (born 1960), BBC correspondent
- David Willis (Australian footballer) (born 1968), Australian rules footballer
- Dave Willis (born 1970), American voice actor, writer, and producer
- Dave Willis (comedian) (1895–1973), Scottish comedian and actor
- Ski (record producer) (born David Willis), American record producer
- David Willis (artist) (born 1932), Irish artist
- David Willis (linguist), linguist and Celticist
- David Willis (politician), member of the North Carolina House of Representatives