De Blasio is a surname of people including:
- Antonio De Blasio (born 1955), Hungarian politician
- Bill de Blasio (born 1961), American politician
- Abele De Blasio [it] (1858–1945), Italian antropologist
- Alfonso De Blasio [it] (1849–1930), Italian politician
- Carlo de Blasio [it] (born 1960), Italian journalist
- Filippo de Blasio [it] (1820–1873), Italian jurist
- Giuseppe de Blasio [it] (1892–1979), Italian journalist
- Luigi De Blasio Di Palizzi [it] (1838–1896), Italian politician
- Mino De Blasio [it] (1954–2010), Italian writer
- Tiberio De Blasio Di Palizzi [it] (1827–1873), Italian politician
- Vincenzo De Blasio Di Palizzi [it] (1839–1906), Italian politician