| Namesake | Hernando de Soto |
|---|---|
| Maintained by | Bureau of Street Services, Los Angeles Department of Water and Power |
| Length | 7.5 mi (12.1 km) |
| Nearest metro station |   De Soto |
| North end | Browns Canyon Road in Chatsworth |
| Major junctions |  SR 118 US 101 |
| South end | Ventura Boulevard in Woodland Hills |
De Soto Avenue is a north–south arterial road that runs for 7.5 miles (12.1 km) between US 101 and SR 118 in the San Fernando Valley in Los Angeles, California.