Death receptor 6

TNFRSF21
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNFRSF21, BM-018, CD358, DR6, tumor necrosis factor receptor superfamily member 21, TNF receptor superfamily member 21
External IDsOMIM: 605732; MGI: 2151075; HomoloGene: 8696; GeneCards: TNFRSF21; OMA:TNFRSF21 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014452

NM_178589

RefSeq (protein)

NP_055267

NP_848704

Location (UCSC)Chr 6: 47.23 – 47.31 MbChr 17: 43.33 – 43.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways.[5][6] It is mostly expressed in the thymus, spleen and white blood cells.[7] The Gene for DR6 is 78,450 bases long and is found on the 6th chromosome. This is transcribed into a 655 amino acid chain weighing 71.8 kDa. Post transcriptional modifications of this protein include glycosylation on the asparagines at the 82, 141, 252, 257, 278, and 289 amino acid locations.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146072Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023915Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Letters. 431 (3): 351–6. Bibcode:1998FEBSL.431..351P. doi:10.1016/S0014-5793(98)00791-1. hdl:2027.42/116991. PMID 9714541. S2CID 11151198.
  6. ^ "Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21".
  7. ^ Salido GM, Rosado JA (2009). Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis. Heidelberg, Germany: Springer. p. 37. ISBN 9781402098734.
  8. ^ Cite error: The named reference Mungall_2003 was invoked but never defined (see the help page).