Decay-accelerating factor

CD55
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD55, CR, CROM, DAF, TC, CD55 molecule (Cromer blood group), CHAPLE
External IDsOMIM: 125240; MGI: 104849; HomoloGene: 479; GeneCards: CD55; OMA:CD55 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007827
NM_001317361

RefSeq (protein)

NP_000565
NP_001108224
NP_001287831
NP_001287832
NP_001287833

NP_001304290
NP_031853
NP_001391877

Location (UCSC)Chr 1: 207.32 – 207.39 MbChr 1: 130.32 – 130.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene.[5]

DAF regulates the complement system on the cell surface. It recognizes C4b and C3b fragments that are created during activation of C4 (classical or lectin pathway) or C3 (alternative pathway). Interaction of DAF with cell-associated C4b of the classical and lectin pathways interferes with the conversion of C2 to C2b, thereby preventing formation of the C4b2a C3-convertase, and interaction of DAF with C3b of the alternative pathway interferes with the conversion of factor B to Bb by factor D, thereby preventing formation of the C3bBb C3 convertase of the alternative pathway. Thus, by limiting the amplification convertases of the complement cascade, DAF indirectly blocks the formation of the membrane attack complex.[6]

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196352Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026401Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML (April 1987). "Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 2007–11. Bibcode:1987PNAS...84.2007M. doi:10.1073/pnas.84.7.2007. PMC 304572. PMID 2436222.
  6. ^ "Molecular function for CD55 Gene".