Deoxycytidine kinase

DCK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P5Z, 1P60, 1P61, 1P62, 2A2Z, 2A30, 2A7Q, 2NO0, 2NO1, 2NO6, 2NO7, 2NO9, 2NOA, 2QRN, 2QRO, 2ZI3, 2ZI4, 2ZI5, 2ZI6, 2ZI7, 2ZI9, 2ZIA, 3HP1, 3IPX, 3IPY, 3KFX, 3MJR, 3QEJ, 3QEN, 3QEO, 4JLJ, 4JLK, 4JLM, 4JLN, 4KCG, 4L5B, 4Q18, 4Q19, 4Q1A, 4Q1B, 4Q1C, 4Q1D, 4Q1E, 4Q1F
Identifiers
Aliases	DCK, entrez:1633, deoxycytidine kinase
External IDs	OMIM: 125450; MGI: 102726; HomoloGene: 616; GeneCards: DCK; OMA:DCK - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	71,030,914 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	88,931,140 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; buccal mucosa cell; ; monocyte; ; appendix; ; lymph node; ; secondary oocyte; ; ventricular zone; ; bone marrow; ; superficial temporal artery; ; ganglionic eminence;
	Top expressed in
	human fetus; ; medial ganglionic eminence; ; gastrula; ; abdominal wall; ; barrel cortex; ; thymus; ; Rostral migratory stream; ; Gonadal ridge; ; primitive streak; ; precursor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleoside kinase activity; deoxycytidine kinase activity; ATP binding; protein homodimerization activity; kinase activity; deoxynucleoside kinase activity;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process; purine-containing compound salvage; nucleobase-containing compound metabolic process; phosphorylation; deoxyribonucleoside monophosphate biosynthetic process; nucleotide biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1633
	13178
	ENSG00000156136
	ENSMUSG00000029366
	P27707
	P43346
	NM_000788
	NM_007832
	NP_000779
	NP_031858
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans.^[5] dCK predominantly phosphorylates deoxycytidine (dC) and converts dC into deoxycytidine monophosphate. dCK catalyzes one of the initial steps in the nucleoside salvage pathway^[6] and has the potential to phosphorylate other preformed nucleosides, specifically deoxyadenosine (dA) and deoxyguanosine (dG), and convert them into their monophosphate forms.^[7] There has been recent biomedical research interest in investigating dCK's potential as a therapeutic target for different types of cancer.^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156136 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029366 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: DCK deoxycytidine kinase".
^ ^a ^b Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG (March 2014). "Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication". The Journal of Experimental Medicine. 211 (3): 473–86. doi:10.1084/jem.20131738. PMC 3949575. PMID 24567448.
^ ^a ^b Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A (July 2003). "Structure of human dCK suggests strategies to improve anticancer and antiviral therapy". Nature Structural Biology. 10 (7): 513–9. doi:10.1038/nsb942. hdl:11858/00-001M-0000-0012-F0B9-8. PMID 12808445. S2CID 6212685.
^ Cite error: The named reference :2 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156136 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029366 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DCK deoxycytidine kinase".

[Nathanson_2014-6] Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG (March 2014). "Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication". The Journal of Experimental Medicine. 211 (3): 473–86. doi:10.1084/jem.20131738. PMC 3949575. PMID 24567448.

[:1-7] Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A (July 2003). "Structure of human dCK suggests strategies to improve anticancer and antiviral therapy". Nature Structural Biology. 10 (7): 513–9. doi:10.1038/nsb942. hdl:11858/00-001M-0000-0012-F0B9-8. PMID 12808445. S2CID 6212685.

[:2-8] Cite error: The named reference :2 was invoked but never defined (see the help page).

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