| 1880 season | |||
|---|---|---|---|
| Captain | Robert Smith | ||
| Most runs | Thomas Foster | ||
| Most wickets | William Mycroft | ||
| Most catches | Alfort Smith | ||
| |||
Derbyshire County Cricket Club in 1880 was the tenth season of the English cricket club Derbyshire.
Derbyshire played Lancashire and Yorkshire, whom they had played in the previous season. However, instead of Hampshire and Nottinghamshire, they played against Sussex for the first time and Kent, whom they had played in a previous season.