Dermatopontin

DPT
Identifiers
AliasesDPT, TRAMP, dermatopontin
External IDsOMIM: 125597; MGI: 1928392; HomoloGene: 1458; GeneCards: DPT; OMA:DPT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001937

NM_019759

RefSeq (protein)

NP_001928

NP_062733

Location (UCSC)Chr 1: 168.7 – 168.73 MbChr 1: 164.62 – 164.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene.[5][6] Dermatopontin is a 22-kDa protein of the noncollagenous extracellular matrix (ECM) estimated to comprise 12 mg/kg of wet dermis weight.[7] To date, homologues have been identified in five different mammals and 12 different invertebrates with multiple functions.[8] In vertebrates, the primary function of dermatopontin is a structural component of the ECM (interaction with decorin and modification of collagen fibrillogenesis), cell adhesion, modulation of TGF-β activity and cellular quiescence). It also has pathological involvement in heart attacks (increased expression around myocardial infarct zone) and decreased expression in leiomyoma and fibrosis. In invertebrate, dermatopontin homologue plays a role in hemagglutination, cell-cell aggregation, and expression during parasite infection.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143196Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026574Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Superti-Furga A, Rocchi M, Schäfer BW, Gitzelmann R (August 1993). "Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin)". Genomics. 17 (2): 463–7. doi:10.1006/geno.1993.1348. PMID 8104875.
  6. ^ "Entrez Gene: DPT dermatopontin".
  7. ^ Krishnaswamy VR, Korrapati PS (December 2014). "Role of dermatopontin in re-epithelialization: implications on keratinocyte migration and proliferation". Scientific Reports. 4: 7385. Bibcode:2014NatSR...4E7385K. doi:10.1038/srep07385. PMC 4260223. PMID 25486882.
  8. ^ a b Okamoto O, Fujiwara S (2006). "Dermatopontin, a novel player in the biology of the extracellular matrix". Connective Tissue Research. 47 (4): 177–89. doi:10.1080/03008200600846564. PMID 16987749. S2CID 23944137.