Desmoglein-3

DSG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EQX
Identifiers
Aliases	DSG3, CDHF6, PVA, desmoglein 3, ABOLM
External IDs	OMIM: 169615; MGI: 99499; HomoloGene: 55513; GeneCards: DSG3; OMA:DSG3 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	31,478,702 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	20,680,516 bp
RNA expression pattern
	Top expressed in
	gums; ; gingival epithelium; ; mucosa of pharynx; ; oral cavity; ; body of tongue; ; human penis; ; vulva; ; cervix epithelium; ; skin of thigh; ; skin of abdomen;
	Top expressed in
	esophagus; ; skin of external ear; ; conjunctival fornix; ; cornea; ; lip; ; skin of back; ; skin of abdomen; ; hair follicle; ; lumbar spinal ganglion; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding;
Cellular component	integral component of membrane; cytosol; cell junction; desmosome; extracellular exosome; membrane; plasma membrane; cornified envelope; cell-cell junction;
Biological process	cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1830
	13512
	ENSG00000134757
	ENSMUSG00000056632
	P32926
	O35902
	NM_001944
	NM_030596
	NP_001935
	NP_085099
	Wikidata
View/Edit Human	View/Edit Mouse

Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.^[5]^[6] In the skin epidermis Desmoglein-3 is expressed in the basal lower layers of the epidermis, and dominates in terms of expression on mucosal surfaces compared to Desmoglein-1.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134757 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056632 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arnemann J, Spurr NK, Buxton RS (May 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Human Genetics. 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426. S2CID 30558450.
^ "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)".
^ Beigi PK (2018). A Clinician's Guide to Pemphigus Vulgaris. Springer, Cham. pp. 3–10. doi:10.1007/978-3-319-67759-0_1. ISBN 9783319677583.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134757 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056632 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1601426-5] Arnemann J, Spurr NK, Buxton RS (May 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Human Genetics. 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426. S2CID 30558450.

[entrez-6] "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)".

[Beigi_2018-7] Beigi PK (2018). A Clinician's Guide to Pemphigus Vulgaris. Springer, Cham. pp. 3–10. doi:10.1007/978-3-319-67759-0_1. ISBN 9783319677583.

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