Dicer

DICER1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW
External IDsOMIM: 606241; MGI: 2177178; HomoloGene: 13251; GeneCards: DICER1; OMA:DICER1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195573
NM_001271282
NM_001291628
NM_030621
NM_177438

NM_148948

RefSeq (protein)

NP_001182502
NP_001258211
NP_001278557
NP_085124
NP_803187

NP_683750

Location (UCSC)Chr 14: 95.09 – 95.16 MbChr 12: 104.65 – 104.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA). [5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100697Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041415Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kyriakidis I, Pelagiadis I, Katzilakis N, Stratigaki M, Keklikoglou I, Tragiannidis A, et al. (Sep 2024). "DICER1 rs3742330 and AGO1 rs636832 polymorphisms and acute lymphoblastic leukemia in Greek children and adolescents: A case-control study". Gene Reports. 37 (December 2024): 102043. doi:10.1016/j.genrep.2024.102043.