Diffuse neonatal hemangiomatosis

Diffuse neonatal hemangiomatosis
SpecialtyDermatology

Diffuse neonatal hemangiomatosis (DNH) is a potentially fatal disorder where multiple benign (non-cancerous) blood vessel tumors (hemangiomas) are present in the skin and other organs.[1] The mortality rate of diffuse neonatal hemangiomatosis is 50-90%. This disease is normally found in female Caucasian infants.[2] The most common site of internal organ damage, or lesions, is the liver, which can redirect blood away from the heart and cause arteriovenous shunting. This can cause high cardiac output, leading to further complications such as congestive heart failure.[2][3] This condition affecting the liver is also known as infantile hepatic hemangioma (IHH).[4] Other sites of internal organ damage can include the intestines, nervous system, lungs, and sometimes the skeletal system.[2] Early detection and treatment with steroids results in most newborn babies with this disease remaining healthy, with serious problems developing for some individuals during the hemangioma's growth phase.[5]

  1. ^ Rapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ a b c Agarwal S, Sharma A, Maria A (July 2017). "Diffuse neonatal hemangiomatosis presenting as congestive heart failure". Dermatology Practical & Conceptual. 7 (3): 66–69. doi:10.5826/dpc.0703a15. PMC 5661156. PMID 29085724.
  3. ^ Upton A (2005). "Diffuse Neonatal Hemangiomatosis". Journal of Diagnostic Medical Sonography. 21 (4): 350–353. doi:10.1177/8756479305278971. ISSN 8756-4793. S2CID 57968601.
  4. ^ Rodrigues A, Forno A, Costa E, Berenguer A, Pilar C, Loureiro R, et al. (August 2018). "Diffuse infantile hepatic haemangioma-how to manage an incidental but potentially lethal finding". Oxford Medical Case Reports. 2018 (8): omy054. doi:10.1093/omcr/omy054. PMC 6105109. PMID 30151220.
  5. ^ Yousenasna L (February 2007). "Neonatal hemangiomatosis". Dermatology Nursing. 19 (1): 86. PMID 17330561.