Dihydroergocryptine

Dihydroergocryptine
Clinical data
Trade names	Almirid, Cripar
Other names	DHEC; 12'-Hydroxy-2'-(1-methylethyl)-5'α-(2-methylpropyl)-9,10α-dihydroergotaman-3',6',18-trione; (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-ergotaman-3',6',18-trione
Pregnancy; category	Contraindicated;
Routes of; administration	Oral
ATC code	N04BC03 (WHO) (alpha/beta);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	12–16 hours
Identifiers
	IUPAC name (2R,4R,7R)-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo- 4-(propan-2-yl)-3-oxa-6,9-diazatricyclo [7.3.0.02,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo [7.6.1.02,7.012,16] hexadeca-1(16),9,12,14-tetraene-4-carboxamide;
CAS Number	25447-66-9 ;
PubChem CID	114948;
ChemSpider	102887 ;
UNII	67V3FSL2GL;
ChEBI	CHEBI:59919 ;
ChEMBL	ChEMBL1743263;
CompTox Dashboard (EPA)	DTXSID5048689 ;
ECHA InfoCard	100.042.706
Chemical and physical data
Formula	C32H43N5O5
Molar mass	577.726 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3N1CCC[C@H]1[C@]2(O)O[C@](C(=O)N2[C@H]3CC(C)C)(NC(=O)[C@@H]6C[C@@H]7c4cccc5c4c(c[nH]5)C[C@H]7N(C)C6)C(C)C;
	InChI InChI=1S/C32H43N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,15,17-18,20,22,24-26,33,41H,7,10-14,16H2,1-5H3,(H,34,38)/t20-,22-,24-,25+,26+,31-,32+/m1/s1 ; Key:PBUNVLRHZGSROC-VTIMJTGVSA-N ;
	(verify)

Dihydroergocryptine (DHEC), sold under the brand names Almirid and Cripar among others, is a dopamine agonist of the ergoline group that is used as an antiparkinson agent in the treatment of Parkinson's disease.^[1] It is taken by mouth.^{[citation needed]}

^ Battistin L, Bardin PG, Ferro-Milone F, Ravenna C, Toso V, Reboldi G (January 1999). "Alpha-dihydroergocryptine in Parkinson's disease: a multicentre randomized double blind parallel group study". Acta Neurologica Scandinavica. 99 (1): 36–42. doi:10.1111/j.1600-0404.1999.tb00655.x. PMID 9925236. S2CID 45192184.