Dipeptidase 2

DPEP2
Identifiers
Aliases	DPEP2, MBD2, dipeptidase 2
External IDs	OMIM: 609925; MGI: 2442042; HomoloGene: 49703; GeneCards: DPEP2; OMA:DPEP2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,000,586 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; right lung; ; lymph node; ; bone marrow; ; upper lobe of left lung; ; testicle; ; appendix;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; metalloexopeptidase activity; dipeptidyl-peptidase activity; metallopeptidase activity; hydrolase activity; metal ion binding; dipeptidase activity;
Cellular component	anchored component of membrane; membrane;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	64174
	319446
	ENSG00000167261
	ENSMUSG00000053687
	Q9H4A9
	Q8C255
	NM_022355; NM_001324159; NM_001369657
	NM_001301204; NM_001301205; NM_176913
	NP_001311088; NP_071750; NP_001356586
	NP_001288133; NP_001288134; NP_795887
	Wikidata
View/Edit Human	View/Edit Mouse

Dipeptidase 2 (DPEP2) is a protein which in humans is encoded by the DPEP2 gene.^[4]

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D₄, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167261 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. S2CID 15252871.
^ "Entrez Gene: Dipeptidase 2".