Diphenoxylate

Diphenoxylate

Clinical data
Other names	R-1132, NIH-756
AHFS/Drugs.com	Monograph
Routes of administration	Oral
Drug class	Opioid Antidiarrheal
ATC code	A07DA01 (WHO)
Legal status
Legal status	AU: S3 (OTC, packs of up to 8x tablets combined with Atropine) & S4 (Rx Only, as S3 but larger pack sizes) & S8 (Controlled, all other preparations) BR: Class A1 (Narcotic drugs)[1] CA: Schedule I DE: Prescription only (Anlage II for higher doses) if combined with atropine sulphate UK: Class A US: Schedule II (alone) and V (with atropine)
Pharmacokinetic data
Protein binding	74–95%
Elimination half-life	12–14 hours
Identifiers
IUPAC name ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate
CAS Number	915-30-0 Y
PubChem CID	13505
IUPHAR/BPS	7164
DrugBank	DB01081 Y
ChemSpider	12919 Y
UNII	73312P173G
KEGG	D07861 Y
ChEBI	CHEBI:4639 Y
ChEMBL	ChEMBL1201294 N
CompTox Dashboard (EPA)	DTXSID8022951
ECHA InfoCard	100.011.837
Chemical and physical data
Formula	C30H32N2O2
Molar mass	452.598 g·mol−1
3D model (JSmol)	Interactive image
SMILES N#CC(c1ccccc1)(c2ccccc2)CCN4CCC(c3ccccc3)(C(=O)OCC)CC4
InChI InChI=1S/C30H32N2O2/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27/h3-17H,2,18-23H2,1H3 Y Key:HYPPXZBJBPSRLK-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridium difficile infection.