Distal renal tubular acidosis | |
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Other names | Type 1 renal tubular acidosis |
Radiograph of a person with rickets, a complication of both distal and proximal RTA. |
Distal renal tubular acidosis (dRTA) is the classical form of RTA, being the first described. Distal RTA is characterized by a failure of acid secretion by the alpha intercalated cells of the distal tubule and cortical collecting duct of the distal nephron.[1] This failure of acid secretion may be due to a number of causes. It leads to relatively alkaline urine, due to the kidney's inability to acidify the urine to a pH of less than 5.3.[citation needed]