Dorena is an unincorporated community in southeastern Mississippi County, Missouri, United States. Route 77 and Route 102 intersect here, approximately thirteen miles southeast of East Prairie.[1] Dorena lends its name to the nearby Dorena-Hickman Ferry, which connects Route 77 with the Kentucky side of the Mississippi River.[2]
A post office called Dorena was established in 1899, and closed in 1973.[3] The name is believed to be derived from an old slang term for money.[4]